T-Rex: The saddest thing I can imagine is a kid who's very sick, but who still loves to play marbles in the park! He's got a mobile IV, and one day it gets stuck in a storm drain on his way to the park, and in trying to free it, he loses all his marbles in the sewer.

T-Rex: Aww! I'm sorry, imaginary dude!

Dromiceiomimus: That is pretty sad, T-Rex! If you want some advice, my secret to making things sad has always been in filling out the background details. If the parents gave the kid the marbles BEFORE he got sick, and if this simple luxury was the last they could afford before the medical bills started coming in, that makes it more sad, I think!
T-Rex: It's true! Huh! Thanks for the advice, Dromiceiomimus.

Utahraptor: And you could make it even sadder by turning the boy into a puppy!
T-Rex: Huh?

Utahraptor: A puppy! My secret to sadness has always been to take something sad, and then imagine it's happening to a poor little puppy dog with a broken leg.
T-Rex: It TOTALLY works! I just thought that losing a job would be sad, but a poor little injured puppy losing its job? That's heartbreaking!

Narrator: LATER: T-REX TURNS UP THE CHARM!
T-Rex: Dromiceiomimus! I've come up with a new saddest thing ever!
Off panel: What's that, T-Rex?
T-Rex: A universe where we never became friends.
T-Rex and off panel: Awww!